Slay The Spire – How to Win Your First Run (Beginner Guide)

If you just started playing Slay The Spire and struggle to complete your first run, this video breaks down the practical choices that helped me finally win. I cover card pickup discipline, balancing offense and defense, relic selection, map routing (elites, merchants, campfires), when to remove cards, and why mixing synergies often beats strict specialization. Examples include Silent tips like poison + shiv mix, taking a rare with a curse, and why Corpse Explosion and Ring of the Snake can carry runs. How to win your first run in Slay The Spire? How to build a beginner Silent deck in Slay The Spire? How to choose relics, use campfires and plan routes in Slay The Spire? 0:00 Intro – What this video teaches 0:19 Common beginner problems and mindset 0:39 Tip 1: Don’t pick every offered card 0:58 Tip 2: Balance offense and defense 1:16 Tip 3: Think before taking relics (boss relics warning) 2:12 Deck building: mix synergies vs strict focus (Silent example) 3:36 Map planning – merchants, elites, treasures, campfires 4:32 Campfires, relics and card removal priorities (curse first) 5:08 Final advice – experiment, don’t ragequit, and be patient 6:14 Character notes: Silent vs Defect, Watcher, Ironclad 6:44 Outro and final tips #SlayTheSpire #SlayTheSpireTips #Roguelike #BeginnerGuide